Pyruvate is a product of glycolysis, the first step in the breakdown of glucose to produce energy, and a key intermediate of several metabolic pathways in the cell. Pyruvate has been proposed to aid with lipid metabolism through reversible conversion to phosphoenolpyruvate and to increase glucose uptake by skeletal muscles, providing a potential for weight loss =. There were seven RCTs published between 1992 and 2009, none of which were categorized as having an overall low degree of bias. All but one was published in the United States, one was funded by industry, and two did not report their funding. Study duration ranged from 21 days to 6 weeks, with number per arm ranging from 6 to 18 participants. The age of participants ranged from 22.5 to 48.7 years (two studies did not report age). The number of women ranged from 0% to 100%. Easy Ways To Safe Fat Burning Supplement Two studies did not report differences between arms, whereas the authors considered four studies to be statistically significant .